Nitric oxide system

Nitric oxide system

At the end of the 1980s, it was clearly demonstrated that cells produce nitric oxide and that this gaseous molecule is involved in the regulation of the cardiovascular, immune and nervous systems, rather than simply being a toxic pollutant. In the CNS, nitric oxide has an array of functions, such as the regulation of synaptic plasticity, the sleep–wake cycle and hormone secretion. Particularly interesting is the role of nitric oxide as a Janus molecule in the cell death or survival mechanisms in brain cells. In fact, physiological amounts of this gas are neuroprotective, whereas higher concentrations are clearly neurotoxic.

Author affiliations

  1. Department of Chemistry, Biochemistry and Molecular Biology Section, Faculty of Medicine, University of Catania, Catania, Italy.
  2. Institute of Pharmacology, Catholic University School of Medicine, Roma, Italy.
  3. Department of Internal Medicine, Catholic University School of Medicine, Roma, Italy.
  4. Department of Chemistry, Sanders-Brown Center on Aging and Center of Membrane Sciences, University of Kentucky, Lexington, Kentucky, USA.
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Honeywell International, Inc BW Technologies GAXT-N-DL GasAlert Extreme Nitric Oxide (NO) Single Gas Detector, 0-250 ppm Measuring Range, Yellow
BISS (Honeywell International, Inc)
  • Single-gas detector for surveying levels of NO in natural and industrial environments, and in other personal safety, training, research, and ambient air monitoring...
  • Electrochemical cell sensor monitors ambient NO levels continuously
  • Audio, visual, and vibration alarms alert simultaneously when NO gas reaches preset TWA, STEL, low, or high levels
  • LCD screen shows self-test status, alarm set-points, maximum exposure, gas type, alarm level (TWA, STEL, low, or high), and battery life remaining
  • Back-mounted alligator clip allows wearing the unit on a belt, and a concussion-resistant boot helps protect against damage
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