Nitric oxide uses

ROCHESTER, Minn. — Inhaled Nitric Oxide (iNO) is a drug approved by the Food and Drug Administration that is commonly used in term and near-term neonates who have severe respiratory failure caused by pulmonary hypertension. Over the last decade there have been multiple large studies trying to determine a clinical use for iNO in preterm neonates, but despite evidence of short-term benefit, this drug has not been shown to improve long-term outcomes in preemies. Still, the drug is commonly being used in this population, Mayo Clinic Children’s Center and co-authors say in a study published today in the journal Pediatrics.

A 2011 statement released by the National Institute of Child Health and Human Development (NICHD) indicated that available evidence did not support the routine use of iNO in preterm neonates and discouraged the use of this expensive therapy in preterm neonates. In 2014, the American Academy of Pediatrics issued a report with similar statements.

“Despite professional guidance from the NICHD to discourage off-label iNO use, neonatologists in many NICUs throughout the United States continue to use this medication in the most premature of neonates, ” says lead author Marc Ellsworth, M.D., neonatology fellow at the Mayo Clinic Children’s Center.”

Mayo Clinic researchers used data collected by Pediatrix Medical Group, a division of MEDNAX National Medical Group, to identify utilization patterns of iNO in American NICUs in the years surrounding the NICHD statement.

In the population-based study, the researchers found that between 2009 and 2013, the rate of iNO utilization in 23–29 week neonates increased from 5.03 percent to 6.19 percent, a relative increase of 23 percent. Of all neonates who received iNO therapy in 2013, nearly half were less than 34 weeks’ gestation (off label), with these infants accounting for more than half of all first exposure iNO days in each year of the study period.

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