Nitrous oxide anesthesia
Horace Wells was a prominent dentist in Hartford, Connecticut, in the 1830s. Like many dentists of his day, Wells was deeply troubled by the agonizing pain his patients suffered during routine procedures like pulling diseased or rotten teeth without anesthesia — ouch!
In 1844, Wells attended a demonstration — part scientific presentation, part sideshow spectacle — by showman Gardner Colton on the mysterious power of nitrous oxide [source: Gifford]. Colton had briefly attended medical school where he and his classmates experimented with the exhilarating properties of the colorless, odorless gas [source: Encyclopaedia Britannica].
During Colton's show, he administered nitrous oxide to audience volunteers who would burst into fits of giggling befitting a substance commonly known as "laughing gas." At the Hartford show attended by Wells, a delirious volunteer injured his leg on stage, but when Wells quizzed the man about it, he couldn't remember any pain [source: Gifford].
Back at his office the next day, Wells climbed into his own operating chair and asked a colleague, with the help of Colton, to administer nitrous oxide while pulling one of Wells' own troubled teeth. The tooth was yanked and Wells reported feeling not "so much as the prick of a pin" [source: Gifford]. The three men, it seemed, had invented painless dentistry.
Wells was thrilled, and after some training from Colton, went on to perform dozens of similar procedures, each with pain-free results. Believing he had discovered a miracle anesthesia, Wells scheduled a public demonstration of his nitrous oxide technique in 1845 for a crowd of Harvard professors and medical students in Boston.
The big show didn't go so great. In fact, it was a full-on disaster complete with its own name, the "humbug affair." Apparently, Wells' patient, after being administered the nitrous oxide, cried out when Wells began to extract his tooth. Whether it was a moan of delirium, a joke or real pain, the crowd of medical students taunted Wells with jeers of "Humbug!" and "Swindler!" [source: Gifford].